Research Interests
Open to PhD applications in the field of the biology, characterisation and therapeutic targeting of mammalian and microbial proteases. In particular:
- USP17 as a therapeutic target in cancer
- Targeting bacterial proteases as an antimicrobial strategy
- Endocytosis and trafficking of nanoparticles
Current Research Opportunities
Public outreach & key achievements
Optimising intracellular delivery of antibiotic loaded PLGA nanoparticles to macrophages (2024) Alsa'd, A. A., Greene, M. K., Tayyem, M., Elmore, B., Abed, A., Burden, R. E., Gilmore, B. F., Scott, C. J. & Burrows, J. F. International Journal of Pharmaceutics. 664, 124567.
USP17 is required for peripheral trafficking of lysosomes (2022) Lin, J., McCann, A., Sereesongsaeng, N., Burden, J., Alsa'd, A. A. M., Burden, R., Micu, I., Williams, R., Van Schaeybroeck, S., Evergren, E., Mullan, P., Scott, C. & Burrows, J., EMBO Reports. e51932.
USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells (2018) McCann, A. P., Smyth, P., Cogo, F., McDaid, W. J., Jiang, L., Lin, J., Evergren, E., Burden, R. E., Van Schaeybroeck, S., Scott, C. J. & Burrows, J. F. Cell communication and signaling. 16, 77.
Research students
| PhD Title | Identifying drug targets to combat Acinetobacter baumannii infections. |
| Name | Bronagh Elmore |
| Country | United Kingdom |
| Years of Study | 2019 - 2025 |
| PhD Title | Identifying Protease Drug Targets to Combat ESKAPE Pathogen Infections |
| Name | Nezar Faya Al Faya |
| Country | Saudi Arabia |
| Years of Study | 2022 - 2025 |
| PhD Title | Design, synthesis and assessment of CDK inhibitors |
| Name | Mashael Alanazi |
| Country |
Saudi Arabia
|
| Years of Study |
2023 - 2026
|
Alumni: Where are they now
| PhD Title | Therapeutic evaluation of an immunomodulatory nanoparticle in Acute Respiratory Distress Syndrome |
| Name | Dr Michelle Greene |
| Years of Study | 2011 - 2015 |
| Country | United Kingdom |
| Current Position | Senior Postdoctoral Fellow, Future Medicines Institute, Queen’s University Belfast, UK |
| PhD Title | Manipulating PLGA nanoparticle cellular uptake and trafficking |
| Name | Dr Alhareth Alsa’d |
| Years of Study | 2019 - 2022 |
| Country | Jordan |
| Current Position | Assistant Professor, Biopharmaceutics and Clinical Pharmacy Department, Al-Ahliyya Amman University, Jordan |
| PhD Title | The role of deubiquitinating enzyme USP17 in Non-Small Cell Lung Cancer as a potential therapeutic target. |
| Name | Dr Jonathan Burden |
| Years of Study | 2020 - 2024 |
| Country | United Kingdom |
| Current Position | Postdoctoral Fellow, Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, London, UK |