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The Orr group focuses on understanding the immune response to fungal pathogens in order to identify potential immunotherapy targets or stratification factors to stratify patient groups at risk of fungal infections in order to target anti-fungal prophylaxis to patients at highest risk of developing serious fungal infections. We have recently generated novel models to fully dissect the role of C-type lectin-like receptors in anti-fungal immunity and we have identified a system to stratify stem cell transplant patients into groups at 'high risk' or 'low risk' of developing invasive aspergillosis.